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American Society of Microbiology ABMM Sample Questions:
1. The human virome, the collection of viruses that reside in and on the human body, is increasinglyrecognized for its role in health and disease. Which of the following statements regarding the human virome is MOST accurate?
A) The human virome is largely independent of the host's immune status.
B) Bacteriophages, viruses that infect bacteria, are a significant component of the human gut virome.
C) The composition of the human virome is relatively stable over time and is not influenced by environmental factors.
D) The human virome is primarily composed of pathogenic viruses that cause acute infections.
2. A clinical microbiology laboratory is validating a new multiplex PCR assay for the simultaneous detection of several gastrointestinal pathogens, including Salmonella, Shigella, and Campylobacter. To ensure the accuracy and reliability of the assay, it is crucial to include appropriate controls. Which of the following sets of controls would be MOST comprehensive?
A) Positive controls for each target organism, a negative control without template DNA, and an internal amplification control.
B) Positive controls for each target organism and a negative control without any template DNA.
C) Positive controls for each target organism, a negative control without template DNA, an internal amplification control, and a process control to monitor nucleic acid extraction.
D) Positive controls for each target organism, a negative control containing non-target DNA, and a process control to monitor nucleic acid extraction.
3. A patient with a history of neutropenia following chemotherapy develops a rapidly progressive pneumonia.
Bronchoalveolar lavage fluid reveals septate hyphae with acute angle (45-degree) branching. The MOST likely diagnosis is invasive pulmonary aspergillosis caused by:
A) Mucor species
B) Fusarium species
C) Rhizopus species
D) Aspergillus fumigatus
4. Which of the following bacterial genera inherently possesses D-alanyl-D-lactate peptide subunits in its peptidoglycan precursors, conferring natural, high-level resistance to vancomycin?
A) Streptococcus
B) Leuconostoc
C) Staphylococcus
D) Enterococcus (e.g., E. gallinarum, E. casseliflavus carrying vanC)
5. A patient develops a febrile illness with jaundice and dark urine after receiving a blood transfusion.
Laboratory testing reveals an elevated level of unconjugated bilirubin and a positive direct Coombs test.
Serological testing is positive for antibodies against a protozoan parasite that infects erythrocytes. The MOST likely causative agent is:
A) Toxoplasma gondii
B) Plasmodium falciparum
C) Babesia microti
D) Trypanosoma cruzi
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: C | Question # 3 Answer: D | Question # 4 Answer: B | Question # 5 Answer: C |
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