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ACRP ACRP-CP

ACRP-CP

Exam Code: ACRP-CP

Exam Name: ACRP Certified Professional Exam

Updated: Aug 07, 2026

Q & A: 127 Questions and Answers

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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Data Management and Informatics17%- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
- Data reporting
  • 1. Data integrity and security
  • 2. Database lock and data transfer
Clinical Study Operations15%- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
- Project management
  • 1. Vendor and stakeholder management
  • 2. Timeline and budget management
Regulatory and Compliance Requirements17%- ICH Guidelines
  • 1. E8 General Considerations for Clinical Trials
  • 2. E2A Expedited Reporting
  • 3. E9 Statistical Principles
  • 4. E11 Pediatric Trials
  • 5. E6(R2)/E6(R3) Good Clinical Practice
- Compliance procedures
  • 1. Audits and inspections
  • 2. Regulatory submissions and approvals
- International standards
  • 1. Declaration of Helsinki
Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Clinical equipoise and therapeutic misconception
  • 2. Human subject protections and privacy
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Clinical care and management of research participants
  • 1. Informed consent development and review
  • 2. Standard of care vs protocol requirements
  • 3. Continuity of medical care
Study Design and Conduct17%- Study implementation
  • 1. Site selection and activation
  • 2. Investigational product management
  • 3. Study monitoring and oversight
- Study planning
  • 1. Protocol development and amendments
  • 2. Sample size and statistical considerations
  • 3. Study population and eligibility criteria
Professionalism and Ethical Practice15%- Professional standards
  • 1. Confidentiality and conflict of interest
  • 2. Role responsibilities and boundaries
- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education

ACRP Certified Professional Sample Questions:

1. Which of the following is a conflict of interest for a PI conducting a study?

A) A PI that presents at an investigator meeting
B) A PI that votes on the IRB/IEC approval of the protocol
C) A PI who receives payment for the study
D) A PI who is a key opinion leader, writes the protocol


2. An investigator in a multicenter trial reports multiple occurrences of an SAE to the sponsor. Who is responsible for reporting the SAEs to the remaining sites' IRB/IECs?

A) Original reporting investigator
B) Investigator at each site
C) Regulatory authority
D) Study sponsor


3. Centralized monitoring can:

A) Enable appropriate stratification of subject enrollment.
B) Confirm why sites are deviating from the protocol.
C) Indicate the need to send monitors to perform onsite visits.
D) Identify IP accountability and storage issues.


4. The composition of an IDMC/DSMB should include which one of the following?

A) A lead PI for the study
B) A member from the IRB/IEC
C) A clinical scientist who is knowledgeable in the appropriate discipline
D) A sponsor representative who is knowledgeable about the study's unblinded information


5. What would a sponsor use to implement and maintain quality in a study?

A) Protocol signature pages
B) Standard operating procedures
C) Statistical analysis plan
D) Clinical trial agreement


Solutions:

Question # 1
Answer: B
Question # 2
Answer: D
Question # 3
Answer: C
Question # 4
Answer: C
Question # 5
Answer: B

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